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KMID : 0856920080110040181
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Journal of Hospice and Palliative Care
2008 Volume.11 No. 4 p.181 ~ p.187
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Neutrophil-Lymphocyte Ratio as a Prognostic Factor in Terminally Ill Cancer Patients
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Cho Wan-Je
Lee Yong-Jae
Son Ga-Hyun
Shim Jae-Yong
Oh Seung-Min
Lee Hye-Ree
Hwang Hee-Jin
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Abstract
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Purpose: In order to establish efficient palliative treatment plans. It is important to estimate the survival time of a terminally ill cancer patient as accurate as possible. Proper estimation of life expectancy aids not only in improving the quality of life of the patient, it also promotes productive communication between the medical staff and the patient. The aim of this study is to determine the efficacy of neutrophil-lymphocyte ratio as a predictor of survival time in terminally ill cancer patients.
Methods: Between January 2004 and June 2007, 67 terminally ill cancer patients who were admitted or transferred for palliative care, were included. Patients were categorized into three groups by Neutrophil-Lymphocyte Ratio. Demographic characteristics, clinical characteristics and blood samples were analyzed.
Results: In univariate analysis, survival time of the highest Neutrophil-Lymphocyte Ratio group () was significantly shorter than that of the others (hazard ratio (HR)=3.270, P=0.001). After adjustment for low performance status (ECOG score 4) and dyspnea, high Neutrophil-Lymphocyte Ratio () was significantly and independently associated with short survival time (HR=2.907, P=0.007). Neutrophil-Lymphocyte Ratio was also significantly increased before death (P=0.001).
Conclusion: Neutrophil-Lymphocyte Ratio can be useful in predicting life expectancy in terminally ill cancer patients.
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KEYWORD
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Neutrophil-Lymphocyte ratio, Terminal cancer, Survival time, Prognostic factor
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